L-Alanyl-L-Glutamine, with the CAS number 39537-23-0, is a bioactive dipeptide composed of L-alanine and L-glutamine linked by a peptide bond, also known as L-Ala-L-Gln or Alanylglutamine. Its molecular formula is C₈H₁₅N₂O₄, and its molecular weight is 217.22 g/mol. As a stable derivative of L-glutamine, it overcomes the instability of free L-glutamine in aqueous solutions, featuring excellent biocompatibility, high bioavailability, and unique physiological activities, making it widely used in pharmaceuticals, clinical nutrition, biochemistry, and food industries.
Physically, L-Alanyl-L-Glutamine appears as a white to off-white crystalline powder or granular solid. It has a melting point of approximately 215-220℃ (decomposition) and is highly soluble in water, forming a clear and stable aqueous solution, while it is slightly soluble in methanol and ethanol, and insoluble in non-polar solvents. It is optically active, with a specific rotation [α]²⁰/D of +14.0° to +18.0° (in water, c=2). It has low hygroscopicity and remains stable under normal temperature and pressure when stored properly, making it easy to handle and transport.
Chemically, it contains peptide bonds, amino groups, and carboxyl groups, with the peptide bond structure enhancing its stability compared to free L-glutamine—avoiding decomposition during storage and processing. It can be hydrolyzed under physiological conditions to release L-alanine and L-glutamine, which are both essential amino acids for the human body. It is stable under neutral and weakly acidic conditions but may hydrolyze under strong acid, strong alkali, or high-temperature environments, maintaining its structural integrity in most application systems such as cell culture and clinical nutrition preparations.
Its core applications focus on clinical nutrition, pharmaceuticals, and biochemistry. In clinical settings, it is widely used as a component of parenteral and enteral nutrition preparations, especially for patients with malnutrition, postoperative recovery, or severe illness, to supplement amino acids, promote protein synthesis, and enhance immune function. In the pharmaceutical industry, it serves as an intermediate for synthesizing peptide drugs and nutritional supplements, supporting the development of products for regulating intestinal function and improving body metabolism. In biochemistry research, it is used as a biochemical reagent and cell culture additive, promoting cell growth and proliferation. Additionally, it is used as a food additive to enhance nutritional value and improve product quality.
Safety-wise, it is generally recognized as safe (GRAS) for its intended uses, non-toxic and non-irritating under normal handling conditions. It should be stored in a sealed, cool, dry, and dark environment at 2-8℃, away from strong oxidants, moisture, and high temperatures, to prevent hydrolysis and degradation. With its excellent stability, bioavailability, and versatile applications, it is an indispensable raw material in clinical nutrition, pharmaceuticals, and biochemistry fields.
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