N-Glycyl-L-Tyrosine dihydrate, with the CAS number 39630-46-1, is a naturally occurring dipeptide hydrate, also known as Gly-Tyr dihydrate or N-Glycyl-L-3-(4-hydroxyphenyl)alanine dihydrate. Its molecular formula is C₁₁H₁₆N₂O₅·2H₂O, and its molecular weight is 292.28 g/mol. Composed of glycine and L-tyrosine linked by a peptide bond, it is a bioactive dipeptide that exhibits good biocompatibility and physiological activity, widely used in pharmaceuticals, biochemistry, food, and cosmetic fields.
Physically, N-Glycyl-L-Tyrosine dihydrate appears as a white to off-white crystalline powder or needle-like crystals. It has a melting point of 195-200℃ (decomposition) and is soluble in water and hot ethanol, slightly soluble in cold ethanol, and insoluble in non-polar solvents. It is optically active, with a specific rotation [α]²⁰/D of -15.0° to -18.0° (in water, c=2), and the dihydrate form ensures good stability under proper storage conditions.
Chemically, it contains a peptide bond, amino groups, carboxyl groups, and a phenolic hydroxyl group, enabling it to participate in various biochemical and organic reactions. It is stable under neutral and weakly acidic conditions but may hydrolyze under strong acid or alkaline conditions, releasing glycine and L-tyrosine. Its bioactive structure allows it to interact with biological systems, making it valuable in physiological and pharmacological research.
Its core applications include the pharmaceutical and biochemistry fields. It serves as a key biochemical reagent for studying peptide metabolism, enzyme activity, and protein synthesis, and is widely used in cell culture and molecular biology experiments. In the pharmaceutical industry, it is an intermediate for synthesizing peptide drugs, nutritional supplements, and drugs for regulating physiological functions. Additionally, it is used in cosmetics as a skin-nourishing ingredient to improve skin hydration and elasticity, and in the food industry as a nutrient additive to enhance nutritional value.
Safety-wise, it is generally recognized as safe (GRAS) for its intended uses, non-toxic and non-irritating under normal handling. It should be stored in a sealed, cool, dry, and dark environment at 2-8℃, away from strong oxidants, moisture, and high temperatures, to prevent hydrolysis and degradation. With its excellent biocompatibility and versatile applications, it is an important raw material in biochemistry, pharmaceuticals, and daily chemical industries.
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