D-Arginine, with the CAS number 157-06-2, is a chiral D-amino acid, also known as D-(-)-Arginine or D-2-amino-5-guanidinovaleric acid. Its molecular formula is C₆H₁₄N₄O₂, molecular weight is 174.2 g/mol, and it has an EINECS registration number of 205-866-5. As the D-enantiomer of L-arginine (an essential amino acid for humans), it is not directly incorporated into mammalian proteins but exhibits unique properties that make it widely used in pharmaceuticals, food, biochemistry, and other fields.
Physically, D-Arginine appears as a white to off-white crystalline powder or crystalline solid. It is slightly soluble in water and acidic aqueous solutions, with solubility increasing with temperature. It has a decomposition point of approximately 226℃, a specific rotation [α]²⁵/D of -27.6° (in 5mol/L HCl), and a density of roughly 1.2297 g/cm³. Chemically, it is air-sensitive and stable under normal temperature and pressure, but should avoid contact with strong oxidants; it contains two ionizable amino groups and one carboxyl group, enabling acid-base neutralization reactions.
In the pharmaceutical industry, it is a key intermediate for synthesizing peptides, enzyme inhibitors, and anti-hypertensive, anti-tumor, and anti-inflammatory drugs. It also shows potential in treating myocardial ischemia and regulating growth hormone secretion. In biochemistry research, it is widely used as a biochemical reagent for peptide and protein preparation, supporting studies on protein synthesis and metabolism.
In the food industry, it serves as a food additive to enhance the umami and saltiness of products such as meat, condiments, and bread, while improving texture and taste. It is also used as a dietary supplement to boost immunity and assist muscle growth for athletes. Additionally, it acts as an intermediate in organic synthesis, supporting the production of fine chemicals and cosmetics.
Safety-wise, it is generally safe for intended use but may cause digestive discomfort if taken in high doses; allergic reactions are rare but possible. It should be stored at 0-5℃ in a sealed, cool, and dry environment to prevent moisture absorption and degradation. With its versatile applications and unique chiral properties, D-Arginine is an important raw material in multiple high-value fields.
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