trans-Ethyl 4-Aminocyclohexanecarboxylate Hydrochloride, with the CAS number 2084-28-8, is an organic hydrochloride derivative, also known as trans-4-Aminocyclohexanecarboxylic acid ethyl ester hydrochloride. Its molecular formula is C₉H₁₇NO₂·HCl, and its molecular weight is 207.70 g/mol. As a trans-configured cyclohexane derivative with an ethyl ester group, it possesses unique stereochemical properties, excellent chemical reactivity, and good stability, making it widely applied in pharmaceutical synthesis, fine chemical production, and organic research fields.
Physically, it appears as a white to off-white crystalline powder or crystalline solid at room temperature. It is highly soluble in water and moderately soluble in common organic solvents, ensuring good compatibility in both aqueous and organic reaction systems, which facilitates its application in various formulation and synthesis processes. It has good thermal stability under normal temperature and pressure, with no obvious decomposition when stored properly. With low hygroscopicity, it is easy to handle, store, and transport, and its purity is typically above 97%, meeting the strict requirements of reagent-level and industrial-grade applications.
Chemically, it contains key functional groups including an amino group, an ethyl ester group, and a hydrochloride group, which are the basis of its unique chemical properties. The trans configuration of the cyclohexane ring endows it with specific spatial structure and stereoselectivity, making it an ideal chiral building block for organic synthesis and pharmaceutical intermediate preparation. It is stable under neutral and weakly acidic conditions, and can undergo ester hydrolysis, amidation, substitution, and other reactions, providing versatile reactivity for the synthesis of complex organic compounds and high-value pharmaceuticals.
Its core applications focus on pharmaceutical synthesis and fine chemical production. In the pharmaceutical industry, it serves as a key intermediate for synthesizing hemostatic agents, antiviral drugs, central nervous system drugs, and other pharmaceutical products, playing a crucial role in optimizing drug structure and improving drug efficacy. In fine chemical fields, it is used to produce specialty chemicals, chiral ligands, and high-purity organic intermediates. Additionally, it is widely used as a biochemical reagent in laboratory research for studying organic reaction mechanisms, stereoselective synthesis, and chiral recognition.
Safety-wise, it is classified as a mild irritant, with potential irritation to the skin, eyes, and respiratory tract upon direct contact. Proper protective equipment such as gloves and goggles should be worn during handling to avoid exposure. It should be stored in a sealed, dry, cool, and dark environment at room temperature, away from strong oxidants, moisture, and heat sources, to maintain its stability, purity, and chemical activity. With its excellent reactivity, unique stereochemical properties, and wide application prospects, it is an indispensable raw material in pharmaceutical and fine chemical industries.
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