Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride, with the CAS number 61367-07-5, is an organic hydrochloride derivative, also known as trans-4-Aminocyclohexanecarboxylic acid methyl ester hydrochloride. Its molecular formula is C₈H₁₅NO₂·HCl, and its molecular weight is 193.67 g/mol. As a trans-configured cyclohexane derivative, it features unique chemical reactivity, good stability, and high purity, making it widely applied in pharmaceutical synthesis, fine chemical production, and biochemical research fields.
Physically, it appears as a white to almost white crystalline powder or crystalline solid at room temperature. It is highly soluble in water and slightly soluble in common organic solvents, which ensures good compatibility in aqueous reaction systems and formulation processes. It has good thermal stability under normal temperature and pressure, with no obvious decomposition when stored properly. With low hygroscopicity, it is easy to handle, store, and transport, and its purity is usually above 97%, meeting the requirements of reagent-level and industrial-grade applications.
Chemically, it contains key functional groups including an amino group, an ester group, and a hydrochloride group, which determine its unique chemical properties. The trans configuration of the cyclohexane ring endows it with specific spatial structure and stereoselectivity, making it an ideal chiral building block for organic synthesis. It is stable under neutral and weakly acidic conditions, and can undergo ester hydrolysis, amidation, and substitution reactions, providing versatile reactivity for the synthesis of complex organic compounds and pharmaceutical intermediates.
Its core applications focus on pharmaceutical synthesis and fine chemical production. In the pharmaceutical industry, it serves as a key intermediate for synthesizing hemostatic agents, antiviral drugs, and other pharmaceutical products, especially contributing to the synthesis of hemostatic agents that achieve hemostasis by constricting blood vessels. In fine chemical fields, it is used to produce specialty chemicals, chiral ligands, and organic intermediates. Additionally, it is used as a biochemical reagent in laboratory research for studying organic reaction mechanisms and stereoselective synthesis.
Safety-wise, it is classified as a mild irritant, with potential irritation to the skin, eyes, and respiratory tract upon direct contact. Proper protective equipment such as gloves and goggles should be worn during handling. It should be stored in a sealed, dry, cool, and dark environment at room temperature, away from strong oxidants, moisture, and heat sources to maintain its stability and purity. With its excellent reactivity and wide application prospects, it is an indispensable raw material in pharmaceutical and fine chemical industries.
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