D-Lysine HCl, with the CAS number 7274-88-6, is a chiral amino acid hydrochloride derivative, also known as D-Lysine hydrochloride or (R)-2,6-Diaminohexanoic acid hydrochloride. Its molecular formula is C₆H₁₅ClN₂O₂, and its molecular weight is 182.65 g/mol. As the D-enantiomer of L-lysine (an essential amino acid for human body), it is not directly involved in mammalian protein synthesis but possesses unique chemical and biological properties, making it a versatile raw material in pharmaceuticals, food, biochemistry, and other fields.
Physically, D-Lysine HCl appears as a white to off-white crystalline powder or granular solid. It has a melting point of 263-265℃ (decomposition) and is highly soluble in water, slightly soluble in ethanol, and insoluble in chloroform. It has a specific rotation [α]²⁰/D of +25.0° to +28.0° (in water, c=10) and is stable under normal temperature and pressure, with good thermal stability within a suitable storage range.
Chemically, the hydrochloride salt form improves its water solubility and chemical stability compared to free D-lysine. It contains two amino groups and one carboxyl group, enabling it to participate in acid-base neutralization, amidation, and other organic reactions, serving as an important chiral building block in organic synthesis and peptide preparation.
Its core applications include the pharmaceutical industry, where it acts as a key intermediate for synthesizing peptides, enzyme inhibitors, and various pharmaceutical compounds, supporting the development of drugs for regulating physiological functions. In biochemistry research, it is widely used as a biochemical reagent for studying amino acid metabolism, protein synthesis, and cell culture. In the food and feed industry, it serves as a nutrient supplement and additive, enhancing the nutritional value of products and promoting the growth of livestock and poultry.
Safety-wise, D-Lysine HCl is generally recognized as safe (GRAS) for its intended uses, non-toxic and non-irritating under normal handling conditions. It should be stored in a sealed, cool, dry, and dark environment at 2-8℃, away from strong oxidants and moisture, to prevent degradation and moisture absorption. With its excellent chiral properties and wide application prospects, it is an indispensable intermediate in high-value fields such as pharmaceuticals and biochemistry.
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