Orotic acid, with the CAS number 65-86-1, is a naturally occurring pyrimidine carboxylic acid, also known as vitamin B13 or 2,4-dihydroxypyrimidine-5-carboxylic acid. Its molecular formula is C₅H₄N₂O₄, and its molecular weight is 156.10 g/mol. As an essential intermediate in pyrimidine biosynthesis, it plays a crucial role in the formation of nucleic acids (DNA and RNA) and is widely used in pharmaceuticals, food nutrition, animal feed, and biochemistry research fields.
Physically, Orotic acid appears as a white to off-white crystalline powder or needle-like crystals. It has a melting point of approximately 345-350℃ (decomposition) and is slightly soluble in cold water, more soluble in hot water, and slightly soluble in ethanol, while insoluble in non-polar solvents. It is odorless and tasteless, with low hygroscopicity and good stability under normal temperature and pressure when stored properly, facilitating easy handling, storage, and formulation.
Chemically, it contains a pyrimidine ring, two hydroxyl groups, and a carboxyl group—key functional groups that determine its biological and chemical properties. It is a weak acid and can form salts with metal ions (such as zinc, magnesium) to improve solubility and bioavailability. As a key intermediate in pyrimidine metabolism, it participates in the synthesis of uridine monophosphate (UMP), which is further involved in the formation of other pyrimidine nucleotides, supporting cell growth and replication.
Its core applications cover multiple fields. In the pharmaceutical industry, it serves as a raw material for preparing liver-protective drugs, nutritional supplements, and drugs for treating pyrimidine deficiency-related diseases, helping to improve liver function and promote nucleic acid synthesis. In food nutrition, it is used as a functional food additive to enhance nutritional value, especially in infant formulas and health products.
In animal feed, it acts as a feed additive to promote animal growth, improve feed conversion rate, and enhance immune function. In biochemistry research, it is used as a biochemical reagent for studying pyrimidine metabolism, nucleic acid synthesis, and cell proliferation. Safety-wise, it is generally recognized as safe (GRAS), non-toxic and non-irritating under normal handling. It should be stored in a sealed, cool, dry, and dark environment, away from oxidants, moisture, and high temperatures to prevent decomposition. With its unique biological functions and versatile applications, it is an important raw material in pharmaceuticals, nutrition, and life science research.
![ODM Trans-4-[(Tert-Butoxycarbonyl)Amino] Cyclohexanecarboxylic Acid Pharmaceutical Intermediates CAS 53292-89-0](http://img.protectedaminoacid.com/photo/pl221176705-odm_trans_4_tert_butoxycarbonyl_amino_cyclohexanecarboxylic_acid_pharmaceutical_intermediates_cas_53292_89_0.jpg)
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