Phospho-L-Tyrosine Disodium Salt (CAS: 1610350-91-8) Product Introduction
Phospho-L-Tyrosine Disodium Salt, with the CAS number 1610350-91-8, is a phosphorylated derivative of L-tyrosine, also known as Disodium Phospho-L-tyrosinate or L-Tyrosine O-phosphate disodium salt. Its molecular formula is C₉H₁₁NNa₂O₆P, and its molecular weight is 307.14 g/mol. As a key phosphorylated amino acid derivative, it mimics the phosphorylated state of tyrosine residues in proteins, playing an irreplaceable role in biochemistry, molecular biology research, and pharmaceutical development.
Physically, it presents as a white to off-white crystalline powder or amorphous solid. It has a decomposition point of approximately 200℃ and is highly soluble in water, forming a clear aqueous solution, while it is slightly soluble in methanol and ethanol, and insoluble in non-polar solvents. It is optically active, with a specific rotation [α]²⁰/D of -15.0° to -19.0° (in water, c=1), and remains stable under cool, dry conditions, but is sensitive to high temperatures and strong acids.
Chemically, it contains a phosphate group, amino group, carboxyl group, and phenolic hydroxyl group, with the disodium salt form significantly improving its water solubility and stability compared to the free acid form. The phosphate group is critical for its biological activity, as it can specifically bind to tyrosine kinase and phosphatase, enabling it to regulate protein phosphorylation-dephosphorylation processes, which are essential for cell signaling, proliferation, and differentiation.
Its core applications focus on biochemical research and pharmaceutical fields. In molecular biology, it is widely used as a standard reagent for detecting tyrosine phosphorylation, studying protein kinase activity, and exploring cell signaling pathways. It also serves as a key intermediate for synthesizing peptide drugs, especially those targeting tyrosine kinase-related diseases. Additionally, it is used in the development of diagnostic reagents and biochemical kits, supporting research on cancer, inflammation, and other diseases.
Safety-wise, it is a mild and non-toxic reagent under normal handling conditions, but proper protective equipment is recommended to avoid direct contact with skin and eyes. It should be stored in a sealed, cool, dry, and dark environment at 2-8℃, away from strong oxidants, strong acids, and high temperatures, to prevent degradation and loss of activity. With its unique biological activity and high solubility, it is an indispensable tool in life science research and pharmaceutical development.
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