Diglycolic anhydride, with the CAS number 4480-83-5, has a molecular formula of C₄H₄O₄ and a molecular weight of 116.07. Its Chinese alias is 1,4-dioxane-2,6-dione, which is a cyclic anhydride formed by the dehydration of diglycolic acid. At room temperature, it presents as a white to off-white crystalline powder or acicular crystal, with a common purity of 90% for industrial grade and up to 98.0% or higher for high-purity grade.
In terms of physical and chemical properties, it has a melting point of 92-98℃ (typical value 92-93℃), a boiling point of 240-241℃, and a boiling point of 130℃ under 20mmHg, with a density of 1.423 g/cm³. It is easily soluble in organic solvents such as chloroform and is sensitive to moisture—when exposed to water, it is prone to hydrolysis and reverts to diglycolic acid, so strict sealed and moisture-proof storage is required.
As a key building block for polymer synthesis, its core value lies in its high reactivity. It can react rapidly with nucleophilic groups such as hydroxyl and amino groups, serving as an important precursor for the preparation of bio-based polyesters, polyamides, and polyesteramides. The resulting materials have both good thermal stability and solubility in organic solvents, which can be used in tissue engineering scaffolds, degradable medical coatings, and environmentally friendly packaging materials.
In the field of functional materials, it can be used for the functional modification of PET nanofibers. By introducing carboxyl groups, it enhances the adsorption selectivity and kinetic efficiency for rare earth elements, contributing to the recovery and resource utilization of rare metals. Meanwhile, it is also a core raw material for preparing degradable network coatings, which can endow the surface of medical devices with anti-biofouling properties and improve the safety of medical materials.
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