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Fmoc-Lys(Dde)-OH is an orthogonally double protected L-lysine derivative with molecular formula C₃₁H₃₆N₂O₆, molecular weight 532.64, CAS 150629-67-7, PubChem CID 135404832. It is a key building block for Fmoc-based solid-phase peptide synthesis (SPPS). The α-amino group is protected by Fmoc group, removable by piperidine, while the ε-amino group is blocked by Dde group, which can be selectively cleaved by hydrazine/DMF without affecting Fmoc. This orthogonal protection enables site-specific side chain modification, branched peptide and cyclic peptide preparation.
• Orthogonal dual protecting groups for selective deprotection • Ideal building block for solid phase peptide synthesis (SPPS) • Enables site-specific peptide labelling & side-chain modification • Stable under standard Fmoc peptide synthesis reaction conditions • High purity for pharmaceutical & research peptide development
Target Industries: Peptide Synthesis, Pharmaceutical Intermediates, Biochemical Research, Custom Peptide Manufacturing Applications: Branched Peptides, Cyclic Peptides, Site-Specific Peptide Modification, Biopharmaceutical R&D
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