Magnesium Orotate, with the CAS number 34717-03-8, is an organic magnesium salt formed by the combination of magnesium ions and orotic acid, also known as Magnesium 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate. Its molecular formula is C₁₂H₁₀MgN₄O₈, and its molecular weight is 378.55 g/mol. It integrates the physiological functions of magnesium and orotic acid, featuring high bioavailability, good biocompatibility, and excellent stability, making it widely applied in pharmaceuticals, nutritional supplements, and health care fields.
Physically, Magnesium Orotate appears as a white to off-white crystalline powder or granular solid. It has a melting point of approximately 300℃ (decomposition) and is slightly soluble in cold water, more soluble in hot water, and slightly soluble in ethanol, while insoluble in non-polar solvents. It is odorless and tasteless, with low hygroscopicity and good stability under normal temperature and pressure when stored properly, facilitating easy handling, storage, and formulation into various dosage forms such as tablets, capsules, and oral solutions.
Chemically, it is a stable organic magnesium complex, where orotic acid acts as a chelating agent to bind magnesium ions, significantly improving the solubility and bioavailability of magnesium compared to inorganic magnesium salts (e.g., magnesium oxide, magnesium carbonate). It retains the core functional groups of orotic acid (pyrimidine ring, carboxyl group) and magnesium ions, enabling it to participate in various physiological processes in the body, including nucleic acid synthesis, energy metabolism, and ion balance regulation.
Its core applications focus on pharmaceuticals and nutritional supplements. In the pharmaceutical industry, it is used as a raw material for preparing drugs to supplement magnesium deficiency, support cardiovascular health, and protect liver function. Magnesium is essential for heart function, nerve transmission, and muscle contraction, while orotic acid promotes nucleic acid synthesis and cell repair, enhancing the therapeutic effect.
In nutritional supplements, it is widely used in health products to provide targeted magnesium supplementation, suitable for populations with magnesium deficiency, such as the elderly, pregnant women, and athletes. It also supports bone health, cognitive function, and energy metabolism. Safety-wise, it is generally recognized as safe (GRAS), non-toxic and non-irritating under normal dosage. It should be stored in a sealed, cool, dry, and dark environment, away from oxidants, moisture, and high temperatures to prevent decomposition. With its high bioavailability and dual physiological benefits, it is a valuable raw material in the health care and pharmaceutical industries.
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